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Identifies neuroplasticity driven by fibroblasts in pancreatic cancer, suggesting new therapeutic targets.
In this issue of Cancer Discovery, Nigri and colleagues identify myofibroblastic cancer-associated fibroblasts as drivers of sympathetic nerve recruitment and activation in pancreatic ductal adenocarcinoma. By uncovering a feedforward stromal-sympathetic circuit, the study establishes neuroplasticity as a fibroblast-orchestrated and therapeutically targetable process that is likely applicable across multiple cancer types. See related article by Nigri et al., p. 1014.
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Hondermarck et al. (2026) studied this question.
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