⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

July 1, 2026

HTLV-1-Infected CD4⁺ T Cells Drive Spontaneous Lymphoproliferation and Virus-Specific CD8⁺ Cytotoxic T Lymphocyte Expansion in HAM/TSP.

Mika Dozono Satoshi Nozuma Takashi Yoshida Daisuke Kodama Toshio Matsuzaki Eiji Matsuura Masakazu Tanaka Hiroshi Takashima Ryuji Kubota

View Full Paper

Ask AI

Bookmark

Share

Key Points

This study aims to investigate the cellular mechanisms behind spontaneous lymphoproliferation in patients with HAM/TSP and the role of HTLV-1-infected T cells.
Analyzed PBMCs from 30 HAM/TSP patients, 12 asymptomatic carriers, and 8 healthy controls.
Cultured cells for 6 days without external stimulation and performed flow cytometry for T-cell profiling.
Measured cytokines and proviral load for further analysis of immune response.
Proliferating HTLV-1-infected T cells predominantly showed a Th1 phenotype with elevated activation and exhaustion markers.
Conditions in HAM/TSP showed significantly higher IL-6 and IFN-γ compared to healthy controls, with IFN-γ correlating to CNS proviral load.
HTLV-1 carriers showed reduced spontaneous proliferation compared to HAM/TSP patients.

No abstract yet

We only have this paper's title and publication details.

Read it at the source→

Implication

Evaluates T cell behaviors in HAM/TSP, indicating mechanisms of lymphoproliferation and immune response.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Dozono et al. (2026) studied this question.

synapsesocial.com/papers/69f6e5cf8071d4f1bdfc66bb https://doi.org/10.1212/nxi.0000000000200581

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Spontaneous lymphoproliferation differentiates two groups of HTLV-1 asymptomatic carriers: with and without high cell proliferation and deathOriginal Research · 2026
2Immunoprofiling of fresh HAM/TSP blood samples shows altered innate cell responsivenessCohort Study · 2021 · 6 citations
3Dendritic Cells Pulsed with HAM/TSP Exosomes Sensitize CD4 T Cells to Enhance HTLV-1 Infection, Induce Helper T-Cell Polarization, and Decrease Cytotoxic T-Cell Response2024 · 3 citations
4PD‐1 and TIM‐3 Expression on Peripheral Blood T Cells in HTLV‐1‐Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) and Their Correlations With Disease Stage and Proviral LoadOriginal Research · 2026
5Transcriptional reprogramming in immune cells of HTLV-1 asymptomatic carriers and HAM/TSP patients following antiretroviral therapy2025