Multidrug resistance to antimicrobial and anticancer drugs has been identified as a global threat by the World Health Organization. Therefore, the search for new biological agents to be used in treatment has accelerated. In this sense, Schiff bases are pharmaceutically important compounds due to the functional group found in their structures, and the investigation of their antimicrobial and anticancer properties has become extremely important. Therefore, in this study, the antimicrobial activities of two different thiazole-ringed Schiff bases against Escherichia coli (ATCC 700728), Pseudomonas aeruginosa (ATCC 27853), Bacillus cereus (NRRL B-3711), Staphylococcus aureus (ATCC 9144), Staphylococcus epidermidis (ATCC 12228), and Candida albicans (NCPF 3179) were investigated. Antimicrobial activities were determined using Disk Diffusion and Minimum Inhibitory Concentration (MIC) methods. Additionally, the in vitro cytotoxic activities of Schiff bases were determined on breast cancer (MCF7) and liver cancer (Mahlavu) cell lines using the MTT method. According to disk diffusion and MIC analysis results, compound 2 was found to be more effective against all microorganisms, exhibited antibacterial activity against Bacillus cereus (MIC = 260.75 µg/mL) comparable to that of the standard antibiotic ampicillin (MIC = 250 µg/mL). Also noteworthy are the cytotoxic activities of both Schiff Bases on cancer cell lines.
Karaca et al. (Tue,) studied this question.