Toward an integrated view of nuclear pore transport.

Luca Lanzano'; Francesco Cardarelli

doi:10.1016/j.tcb.2026.04.002

April 29, 2026

Toward an integrated view of nuclear pore transport.

View Full Paper

Ask AI

Bookmark

Share

Key Points

This research investigates how molecules pass through nuclear pore complexes, aiming to clarify the transport mechanisms involved.
Utilized single-particle tracking to observe transport dynamics.
Employed cargo-centric ensemble assays for analyzing transport events.
Performed fluctuation analyses to assess spatial confining effects in transport.
Identified that transport events are rapid and spatially confined.
Found transport to be biased, supporting a new integrated model of nuclear pore transport.
Provided evidence against a purely passive diffusion mechanism, indicating constrained transport is significant.

Implication

Explores mechanistic transport through nuclear pore complexes, suggesting new understandings.

Abstract

The mechanism of molecular passage through nuclear pore complexes (NPCs) remains debated between passive diffusion and constrained transport. Integrating single-particle tracking, cargo-centric ensemble assays, and fluctuation analyses reveals that productive transport events are rapid, spatially confined, and biased, supporting a convergent phenomenology that provides an integrated view of NPC transport.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Lanzano' et al. (2026) studied this question.

synapsesocial.com/papers/69f6e5f38071d4f1bdfc6915 https://doi.org/10.1016/j.tcb.2026.04.002

View Full Paper

Ask AI

Bookmark

Share

Toward an integrated view of nuclear pore transport.

Key Points

Implication

Abstract

Discussion

Cite This Study

Toward an integrated view of nuclear pore transport.

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading