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This research aims to evaluate the immune-enhancing effects of IBP35 in macrophages and cyclophosphamide-induced immunosuppressed mice.

May 3, 20260 citations

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Immune-Enhancing Effects of IBP35, a Combination of Lactiplantibacillus plantarum and Ligilactobacillus salivarius, in Macrophages and Cyclophosphamide-Induced Immunosuppressed Mice.

HLHan Bin LeePyeongtaek University JLJinho LeePyeongtaek University KJKyuho JeongKwangdong Pharmaceutical

Key Points

This research aims to evaluate the immune-enhancing effects of IBP35 in macrophages and cyclophosphamide-induced immunosuppressed mice.
Utilized a mouse model with induced immunosuppression using cyclophosphamide (CPA)
Administered IBP35, a combination of Lactiplantibacillus plantarum and Ligilactobacillus salivarius
Conducted histological analysis to assess immune responses and organ histology.
IBP35 significantly attenuated CPA-induced splenic atrophy (p<0.001)
IBP35 modulated immune responses without excessive inflammation in healthy mice
Supported innate and adaptive immune function under immunosuppressed conditions.

Abstract

< 0.001). Histological analysis revealed that IBP35 attenuated CPA-induced splenic atrophy and lymphoid depletion. In healthy mice, IBP35 modulated immune responses without inducing excessive inflammation. Collectively, these results indicate that IBP35 modulates both innate and adaptive immune readouts and supports immune function under immunosuppressed conditions.

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Cite This Study

Lee et al. (Fri,) studied this question.

synapsesocial.com/papers/69f6e6648071d4f1bdfc6ff0 https://doi.org/https://doi.org/10.1002/fsn3.71831

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