Research progress on TWEAK/Fn14 signaling in chronic wound healing

Chronic wounds are characterized by persistent inflammation and altered microenvironments, exhibiting prolonged healing and difficult repair, presenting significant therapeutic challenges. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK), by binding to its receptor fibroblast growth factor-inducible 14 (Fn14), participates in cellular regulation, wound repair, and inflammatory response processes, playing an important role in chronic wound healing. This review summarizes the pathophysiological mechanisms of chronic wounds, the mechanisms of action of the TWEAK/Fn14 signaling pathway in chronic wound healing, and the latest research progress on its potential as a therapeutic target.