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This study explores the utilization and impact of hydroxyurea therapy on patients with sickle cell disease in Nigeria.

Access, Adherence and Patient-Reported Outcomes of Hydroxyurea Therapy in Sickle Cell Disease: A Cross-Sectional Study from Nigeria

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Cross-sectional analysis reveals hydroxyurea uptake issues in sickle cell disease patients, indicating a need for support.

This study explores the utilization and impact of hydroxyurea therapy on patients with sickle cell disease in Nigeria.
Conducted a cross-sectional analysis using questionnaire data from 117 adults with sickle cell disease.
Derived composite scores for quality of life and disease burden from survey responses.
Used multivariable logistic regression to identify predictors of hydroxyurea uptake, discontinuation, adherence, and patient-reported outcomes.
42.7% reported current hydroxyurea use, while 14.5% discontinued treatment.
Higher disease burden was significantly associated with increased hydroxyurea uptake (aOR 2.06, 95% CI 1.02–4.13; p=0.043).
Adherence was lower among patients with higher disease burden (aOR 0.27, 95% CI 0.08–0.89; p=0.032) and linked to quality of life improvements.

Korubo et al. (2026) studied this question.

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