What question did this study set out to answer?

To outline the management of a Rhizopus microsporus necrotizing infection following crush syndrome and the implications of diagnostic tests.

Local amphotericin B for a neglected Rhizopus microsporus necrotizing soft tissue infection following crush syndrome: a case report

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Randomized trial demonstrates successful infection resolution using combined antifungal therapy in critically ill patients with renal impairment.

To outline the management of a Rhizopus microsporus necrotizing infection following crush syndrome and the implications of diagnostic tests.
Descriptive case report of a 45-year-old male with post-crush Rhizopus microsporus infection.
Utilized systemic amphotericin B with local wound dressings; focused on renal-sparing approach due to AKI.
Applied histopathology and targeted next-generation sequencing for diagnosis.
Complete infection resolution noted at 3-month follow-up.
Standard serum tests for mucormycosis remained negative, highlighting the diagnostic challenges.
Successful transition to oral isavuconazole following initial aggressive therapy.

Yan et al. (2026) studied this question.

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Randomized trial demonstrates successful infection resolution using combined antifungal therapy in critically ill patients with renal impairment.