Clinical and radiological outcome comparison of unilateral vs. bilateral percutaneous vertebroplasty for osteoporotic vertebral compression fractures

September 30, 2025

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The aim is to compare clinical and radiological outcomes of unilateral versus bilateral percutaneous vertebroplasty in painful osteoporotic vertebral compression fractures.
Retrospective analysis of 203 patients from 2014 to 2024, who underwent percutaneous vertebroplasty
Patients were divided into unilateral (n=104) and bilateral (n=99) treatment groups
Clinical evaluations included VAS and Oswestry Disability Index, while radiological outcomes involved anterior vertebral height restoration and Cobb angle assessment.
Both approaches showed significant pain reduction and functional improvement.
Bilateral vertebroplasty yielded lower postoperative VAS scores (1.9 vs 2.1, p=0.040) and ODI scores (23.1% vs 26.3%, p=0.02) compared to unilateral.
Radiologically, bilateral procedures resulted in higher anterior height restoration (25.8% vs 19.2%, p=0.001) and greater Cobb angle correction (9.1° vs 6.4°, p=0.001).

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Compares clinical and radiological outcomes of unilateral and bilateral vertebroplasty, suggesting individualized treatment.

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Aydın et al. (2025) studied this question.

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