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This research aims to explore the relationship between functional dynamics and structural atrophy in the aging brain.

May 3, 2026

System-Level Reconfiguration of the Aging Brain: Linking Dynamics, Morphology and Micro-architectures.

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Randomized trial examines structural and functional brain dynamics in young and older adults, suggesting critical aging implications.

This research aims to explore the relationship between functional dynamics and structural atrophy in the aging brain.
Utilized resting-state functional MRI data from 252 participants, including 145 young adults and 107 older adults.
Employed three data-driven approaches: normalized Shannon entropy, phase synchronization of BOLD signals, and temporal asymmetry analysis.
Conducted morphometric analyses and partial least squares analysis to examine the correlation between structure and dynamics.
Significant reduction in spatiotemporal complexity was found in older individuals (normalized Shannon entropy).
Enhanced global integration and metastability were present in older adults within key networks (DAN, VAN, FPN).
Widespread structural atrophy correlated with variations in cognitive performance and micro-architecture maps.

Fan et al. (2026) studied this question.

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