Reverse Syphilis Screening Algorithm in a High-Volume Laboratory: CLIA–RPR–TPHA Concordance and Determinants of RPR Reactivity

April 29, 2026Developments and Experiments in Health and Medicine

View Full Paper

Ask AI

Bookmark

Share

Key Points

This study evaluates the diagnostic concordance of CLIA, RPR, and TPHA assays and identifies factors influencing RPR reactivity.
Retrospective analysis of 109,390 serum samples from January 2021 to January 2023.
CLIA-reactive samples underwent RPR testing and TPHA confirmation as necessary.
Logistic regression and ROC analysis used to assess predictors of RPR positivity and CLIA S/CO performance.
Among 995 CLIA-reactive samples, 278 (29.4%) were RPR-positive.
TPHA confirmed 76 (64.4%) of 118 RPR-negative samples as true positives.
Younger age (adjusted OR for 18–45 years: 3.39, 95% CI: 2.10–5.48, p<0.001) and outpatient status were independent predictors of RPR reactivity.

We only have this paper's title and publication details.

Retrospective analysis evaluates diagnostic concordance in a high-volume laboratory, suggesting age and outpatient status impact RPR reactivity.

No takes yet. Share an insight, caveat, or question.

Gülmez et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

Share