What question did this study set out to answer?

This study aimed to evaluate and compare the diagnostic performance of syphilis screening methods in blood donors.

June 7, 2026Asian Journal of Transfusion ScienceOpen Access

Diagnostic accuracy of treponemal and nontreponemal tests for syphilis in blood donors: A 2-year study from Eastern India

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Authors

SDSudipta Sekhar Das SMSourav Mukherjee SCSourav ChowdhuryNizam's Institute of Medical Sciences

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Implication

Cross-sectional study evaluates diagnostic performance of treponemal and nontreponemal tests in blood donors, indicating recommendations for screening improvement.

Key Points

This study aimed to evaluate and compare the diagnostic performance of syphilis screening methods in blood donors.
Cross-sectional observational study screening 27,844 blood donations.
Samples tested using TPHA, CLIA, and RPR with CLIA as the reference standard.
Diagnostic performance parameters calculated, including sensitivity, specificity, and Cohen's kappa.
Syphilis reactivity was 0.28% by TPHA, 0.27% by CLIA, and 0.09% by RPR.
TPHA demonstrated 100% sensitivity and 99.99% specificity; RPR had 34.67% sensitivity.
100% concordance for TPHA and CLIA in external quality assessment samples.

Cite This Study

Das et al. (2026) studied this question.

synapsesocial.com/papers/6a250b8b7def13d035e1b90e https://doi.org/10.4103/ajts.ajts_135_25

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Implication

Cross-sectional study evaluates diagnostic performance of treponemal and nontreponemal tests in blood donors, indicating recommendations for screening improvement.

Diagnostic accuracy of treponemal and nontreponemal tests for syphilis in blood donors: A 2-year study from Eastern India

Discussion

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Implication

Key Points

Cite This Study

Diagnostic accuracy of treponemal and nontreponemal tests for syphilis in blood donors: A 2-year study from Eastern India

Discussion

Member takes

Implication

Key Points

Cite This Study

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