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This study compares syphilis screening practices across different countries and examines the importance of universal donor screening.

August 11, 2026Vox Sanguinis

Mapping syphilis surveillance: Insights into blood donation screening practices worldwide

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Cross-sectional survey compares global syphilis screening and donor reactivity practices, indicating the need for standardized policies.

This study compares syphilis screening practices across different countries and examines the importance of universal donor screening.
Cross-sectional international survey conducted among blood transfusion professionals.
Data reported on syphilis prevalence, screening algorithms, reactivity rates, and donor deferral policies from 2018 to 2024.
Descriptive analyses performed by year and geographic region.
Universal donor screening reported by 35 of 36 institutions, primarily using treponemal assays.
Marked variation in confirmatory testing and donor deferral criteria observed across centres.
First-time donors had higher reactivity rates compared to repeat donors, with higher syphilis rates associated with increased donor reactivity.

García‐Otálora et al. (2026) studied this question.

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