Primary mediastinal (thymic) large B-cell lymphoma should be considered in the differential diagnosis of young patients presenting with Superior vena cava syndrome.
Supports considering PMBCL in the differential for young patients with SVC syndrome; leaves open need for confirmatory studies.
abdominopelvic magnetic resonance imaging was performed in order to differentiate compression versus mass invasion. A gross anterior mediastinal mass (109 × 60 × 105 mm) occupying the totality of the prevascular space was found, extending from the sternal furcula to the pericardium, fully embedding the superior vena cava. A computerized tomography guided biopsy was performed. Histopathological and immunohistochemical analysis was consistent with Primary mediastinal (thymic) large B-cell lymphoma. Primary mediastinal (thymic) large B-cell lymphoma has unique clinicopathologic aspects and it should be considered in a young patient with Superior vena cava syndrome. Prompt recognition, a timely diagnosis and appropriate treatment are crucial for prognosis.
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Besteiro et al. (2021) studied this question.
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