Key result
High concentrations of Lp(a) are associated with incident extracoronary atherosclerotic vascular disease and progression to major complications (P=0.228).
Why the study?
Are high concentrations of Lipoprotein(a) associated with incident extracoronary atherosclerotic vascular disease and progression to major complications in UK Biobank participants?
Cohort (n=460,544)
Are high concentrations of Lipoprotein(a) associated with incident extracoronary atherosclerotic vascular disease and progression to major complications in UK Biobank participants?
p-value: p==0.228
High Lipoprotein(a) concentrations serve as a prognostic marker for incident extracoronary atherosclerotic vascular disease and its major complications.
BACKGROUND: Despite current treatment strategies for atherosclerotic vascular disease focusing on lifestyle modification and lowering cholesterol, a significant residual risk of major atherosclerotic complication remains, prompting investigation into lipoprotein(a) (Lp(a)) as a potential predictive biomarker. The objective of this study was to determine the usefulness of Lp(a) in identifying patients at high risk of incident extracoronary atherosclerotic vascular disease and complications. METHODS: Data from 460 544 participants in the UK Biobank with prospectively measured Lp(a) concentrations were included in this analysis. Cox proportional hazards regressions modeled the associations of Lp(a) concentrations with incident peripheral artery disease (PAD) and incident carotid artery stenosis and progression to the first major adverse limb event and the first stroke, respectively. RESULTS: =0.228). CONCLUSIONS: High concentrations of Lp(a) are associated with both incident extracoronary atherosclerotic vascular disease and progression to major complications.
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Bellomo et al. (2025) conducted a cohort in Extracoronary atherosclerotic vascular disease (n=460,544). Lipoprotein(a) concentrations was evaluated on Incident peripheral artery disease (PAD), incident carotid artery stenosis, and progression to the first major adverse limb event and the first stroke (p==0.228). High concentrations of Lp(a) are associated with incident extracoronary atherosclerotic vascular disease and progression to major complications (P=0.228).
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