This analysis investigates the link between high Lp(a) levels and cardiovascular risks in a large population, suggesting a path for preventive therapies.
Key Points
The study aims to explore the relationship between high lipoprotein(a) levels and the risks of peripheral artery disease, abdominal aortic aneurysm, and major adverse limb events.
Included 108,146 individuals from the Copenhagen General Population Study
Monitored the development of PAD and AAA during follow-up
Replicated findings in the Copenhagen City Heart Study
Higher Lp(a) levels are linked to a significant increase in risk for PAD and AAA (HRs of 2.99 and 2.22 respectively)
For individuals with PAD, the incidence rate ratio for MALE is 3.04
Absolute 10-year risks of PAD in women aged 70 to 79 with high Lp(a) range from 8-21%, and men from 11-29%.