Association of Body Mass Index With Lifetime Risk of Cardiovascular Disease and Compression of Morbidity
Why the study?
Does overweight or obesity increase the lifetime risk of incident cardiovascular disease and years lived with cardiovascular disease in adults compared to normal BMI?
Population
190,672 adults free of clinical CVD at baseline from 10 large US prospective cohorts. Mean age 46.0 years…
Comparison
Overweight, obesity, and morbid obesity vs Normal BMI (18.5-24.9)
Design
Cohort
Follow-up
3.2 million person-years of follow-up from 1964 to 2015
Authors
Discussion
Loading...
Member takes
Implication
May warrant enhanced weight management in middle-aged adults; extends dose-response associations to competing risks but leaves causality open.
Structured PICO
Does overweight or obesity increase the lifetime risk of incident cardiovascular disease and years lived with cardiovascular disease in adults compared to normal BMI?
P
Population
190,672 adults free of clinical CVD at baseline from 10 large US prospective cohorts. Mean age 46.0 (SD 15.0) years for men and 58.7 (SD 12.9) years for women, 73.9% female.
I
Intervention
Overweight (BMI 25.0-29.9), obesity (BMI 30.0-39.9), and morbid obesity (BMI ≥40.0)
C
Comparator
Normal BMI (18.5-24.9)
O
Outcome
Total CVD and CVD subtype (including fatal and nonfatal coronary heart disease, stroke, congestive heart failure, and other CVD deaths), lifetime risks, and years lived free of and with CVDcomposite
Overweight and obesity are associated with a significantly increased lifetime risk of developing cardiovascular disease at an earlier age, leading to a greater proportion of life lived with cardiovascular morbidity.
Cite This Study
Khan et al. (2018) studied this question.