Why the study?
Is invasive pulse wave velocity associated with the severity of aortic valve calcification, pressure gradients, and matrix metalloproteinase levels in patients with degenerative aortic stenosis?
Population
60 patients, comprising 30 with degenerative aortic stenosis and 30 age- and sex-matched controls.
Comparison
Invasive pulse wave velocity measurement… vs Age- and sex-matched control patients without…
Design
Case-control
Authors
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PWV elevation tracks AS severity; hypothesis-generating for shared arteriosclerosis mechanisms, no practice change indicated.
Is invasive pulse wave velocity associated with the severity of aortic valve calcification, pressure gradients, and matrix metalloproteinase levels in patients with degenerative aortic stenosis?
Invasive pulse wave velocity is strongly associated with aortic valve pressure gradients, calcification severity, and matrix metalloproteinase levels in patients with degenerative aortic stenosis, suggesting a link between advanced AV degeneration and severe aortic arteriosclerosis.
Liu et al. (2004) studied this question.
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