July 5, 2005JAMA
Low-Dose Aspirin in the Primary Prevention of Cancer
Why the study?
Does aspirin 100 mg every other day reduce the risk of newly diagnosed invasive cancer in healthy women aged at least 45 years?
Population
39,876 US women aged at least 45 years and initially without previous history of cancer, cardiovascular…
Comparison
Aspirin 100 mg administered every other day vs Aspirin placebo administered every other day
Design
RCT, randomized 2 x 2 factorial trial
Follow-up
average 10.1 years
Authors
Discussion
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Implication
Aspirin 100 mg every other day does not reduce total cancer in healthy women ≥45 years; confirms absence of chemopreventive benefit.
Structured PICO
Does aspirin 100 mg every other day reduce the risk of newly diagnosed invasive cancer in healthy women aged at least 45 years?
P
Population
39,876 US women aged at least 45 years and initially without previous history of cancer, cardiovascular disease, or other major chronic illness
I
Intervention
Aspirin 100 mg administered every other day
C
Comparator
Aspirin placebo administered every other day
O
Outcome
Confirmed newly diagnosed invasive cancer at any site, except for nonmelanoma skin cancerhard clinical
Cite This Study
Cook et al. (2005) studied this question.