A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® l-Theanine on Stress in a Healthy Adult Population

This is the authors' abstract. We don't add key points for this paper.

INTRODUCTION: L-Theanine on whole-scalp and frontal alpha power, midline theta power, and salivary cortisol in healthy, moderately stressed adults. METHODS: L-Theanine (200 mg) or placebo was administered. To induce stress, a mental arithmetic test (MAT) was administered before and after the dose. Electroencephalogram, salivary cortisol, blood pressure, heart rate, self-reported stress, adverse events, clinical chemistry, and hematology were assessed to evaluate efficacy and safety. RESULTS: L-Theanine compared to placebo. CONCLUSION: L-Theanine was found to be safe and well tolerated by participants. TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT04706494.