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This review explores how immune dysregulation at the maternal-fetal interface contributes to preeclampsia and fetal growth restriction.

Inflammation at the Maternal–Fetal Interface: Mechanisms Linking Maternal–Fetal Immunity to Preeclampsia and Fetal Growth Restriction

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This review explores how immune dysregulation at the maternal-fetal interface contributes to preeclampsia and fetal growth restriction.
Synthesis of current knowledge on maternal-fetal immune interactions
Exploration of therapeutic strategies targeting immune dysregulation
Focus on biomarker validation and pathway-specific interventions
Disrupted immune regulation at the maternal-fetal interface leads to placental dysfunction and systemic endothelial dysfunction.
Excessive immune activation is linked to changes in placental perfusion and vascular maladaptation.
Emerging therapies show potential but need rigorous evaluation for safety and efficacy.

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Reviewing mechanisms linking immune dysregulation to preeclampsia and fetal growth restriction, suggesting therapeutic strategies.

Miranda et al. (2026) studied this question.

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