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This study aims to identify optimal stimulation sites and evaluate the functional connectivity associated with treatment response in Meige syndrome.

May 4, 2026

Subthalamic nucleus deep brain stimulation in Meige syndrome: mapping the optimal stimulation sites and network targets.

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This study aims to identify optimal stimulation sites and evaluate the functional connectivity associated with treatment response in Meige syndrome.
Retrospective analysis of long-term outcomes in 65 patients with Meige syndrome undergoing bilateral STN-DBS.
Investigation of local stimulation effects and whole-brain functional connectivity patterns using advanced imaging tools.
Validation of findings through both internal and external cohort comparisons.
STN-DBS resulted in significant motor improvements of 63% in the training cohort and 56% in the validation cohort (p < 0.001).
Optimal stimulation sites were found in the dorsolateral sensorimotor subregion of the STN.
Clinical correlations with connectivity models showed R = 0.59 (p = 0.020) and R = 0.74 (p = 0.002) in independent validation.

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Randomized trial identifies effective stimulation sites in Meige syndrome, suggesting personalized strategies for enhanced DBS outcomes.

Zheng et al. (2026) studied this question.

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