A conserved re-epithelialization program underlies malignancy in pancreatic ductal adenocarcinoma.

Meilian Zhuo; Yong Li; Yifeng Zhang; C R Yang; Di Zou; Wenhao Xu; Jing Han; Saisai Wang; Haohao Deng; Xu Pan; Ruikang Dun; Ruizhe He; Yihong Shi; Xianlin Han; T P Zhang; Weibin Wang; Menghua Dai; Qi Xu; Lulu Liu; Wenze Wang; Yuanhao Liu; Mingyang Liu; Ziqing Deng; Yupei Zhao; W C Wu; Junya Peng; Mo Chen; Charles J. David

doi:10.1016/j.ccell.2026.03.021

Key Points

Investigate the role of a conserved re-epithelialization program in malignancy associated with pancreatic ductal adenocarcinoma.
Analyzed molecular pathways contributing to the malignant process.
Examined the activation of EGFR and its effects on neoplasia.
Findings show that re-epithelialization promotes invasive features in pancreatic ductal adenocarcinoma.
EGFR activation drives a wound-like loop contributing to malignancy.

Implication

Experimental analysis reveals a re-epithelialization program promoting malignancy in pancreatic ductal adenocarcinoma, indicating potential therapeutic targets.

Abstract

state, which in turn promote neoplastic MP10 through EGFR activation, forming a wound-like loop that underlies invasive PDAC.

Discussion

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Cite This Study

Zhuo et al. (2026) studied this question.

synapsesocial.com/papers/69f8375e3ed186a7399817a3 https://doi.org/10.1016/j.ccell.2026.03.021

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A conserved re-epithelialization program underlies malignancy in pancreatic ductal adenocarcinoma.

Key Points

Implication

Abstract

Discussion

Cite This Study

A conserved re-epithelialization program underlies malignancy in pancreatic ductal adenocarcinoma.

Key Points

Implication

Abstract

Discussion

Cite This Study

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