What question did this study set out to answer?

This study evaluates health-related quality of life differences between people living with HIV on first-line INSTI regimens and those switched from efavirenz (EFV) to INSTI.

May 4, 2026

Health-related quality of life in people living with HIV on first-line INSTI versus those switched from EFV to INSTI: a cross-sectional study from four cities in China.

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HJHanlu JiaGuangdong Pharmaceutical University YGYunxia GengChinese Center For Disease Control and Prevention YGYuan GuanFudan University

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Implication

Cross-sectional survey compares HRQOL in HIV patients on first-line INSTI vs. those switched from EFV, suggesting significant factors.

Key Points

This study evaluates health-related quality of life differences between people living with HIV on first-line INSTI regimens and those switched from efavirenz (EFV) to INSTI.
Cross-sectional survey conducted in four tertiary hospitals in China from January to February 2025.
567 participants with INSTI-based regimens were enrolled and assessed for HRQOL using the WHOQOL-HIV BREF instrument.
Multivariable linear regression models analyzed factors associated with HRQOL.
First-line INSTI users reported significantly higher general health scores compared to those switched from EFV (B = 0.21, 95% CI: 0.05 - 0.37, p = 0.011).
Comorbidities negatively impacted general quality of life, health, independence, and social relationships.
Higher education, income, and longer antiretroviral therapy duration correlated with better scores in some HRQOL domains.

Cite This Study

Jia et al. (2026) studied this question.

synapsesocial.com/papers/69f8375e3ed186a7399817bb https://doi.org/10.1186/s12879-026-13411-6

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Health-related quality of life in people living with HIV on first-line INSTI versus those switched from EFV to INSTI: a cross-sectional study from four cities in China.

Discussion

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Implication

Key Points

Cite This Study

Health-related quality of life in people living with HIV on first-line INSTI versus those switched from EFV to INSTI: a cross-sectional study from four cities in China.

Discussion

Member takes

Implication

Key Points

Cite This Study

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