Visible-light-induced diastereoselective synthesis of β-lactams via a Cu( i )-catalyzed cascade 1,5-H shift/cyclization

Ke Zhang; Sinuo Li; Hengrui Zhou; Fang Zhang; Linna Guo; Yunqiang Li; Zhiwei Jiao

doi:10.1039/d6qo00281a

January 1, 2026Organic Chemistry Frontiers

Visible-light-induced diastereoselective synthesis of β-lactams via a Cu( i )-catalyzed cascade 1,5-H shift/cyclization

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Key Points

The aim is to develop an efficient method for synthesizing β-lactams using visible light and a copper catalyst.
Visible-light-driven copper(I)-catalyzed methodology.
Involves a 1,5-H atom transfer and cyclization process.
Focus on achieving good to excellent diastereoselectivity.
The method achieves good to excellent diastereoselectivity in β-lactams synthesis.

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Implication

Demonstrates efficient β-lactam synthesis in a visible-light context, implying broader applications in organic chemistry.

Abstract

A visible-light-driven copper( i )-catalyzed 1,5-HAT/cyclization enables efficient synthesis of β-lactams with good to excellent diastereoselectivity.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69f8375e3ed186a739981873 https://doi.org/10.1039/d6qo00281a

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Visible-light-induced diastereoselective synthesis of β-lactams via a Cu( i )-catalyzed cascade 1,5-H shift/cyclization

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Visible-light-induced diastereoselective synthesis of β-lactams via a Cu( i )-catalyzed cascade 1,5-H shift/cyclization

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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