A mendelian randomization study investigates the causal relationship between oral microbiome and cerebral aneurysm in East Asian population.

BACKGROUND: Growing evidence supports that oral microbiome play an essential role in the etiology of cerebral aneurysm.This study aimed to investigate the causal relationships between the oral microbiome and cerebral aneurysm in the East Asian population using Mendelian randomization (MR). METHODS: Genetic summary data related to oral microbiota and cerebral aneurysm were collected from genome-wide association studies involving participants of East Asian descent. MR estimates were generated by conducting various analyses.Two-sample Mendelian randomization (MR) was utilized to compute the causal effects between the oral microbiome and cerebral aneurysm. RESULTS: In the saliva group, we found causal relationships between 11 oral microbiotas and cerebral aneurysm,9 negative causal associations and 2 positive. In the tongue group, we found causal relationships between 15 oral microbiotas and cerebral aneurysm,9 negative causal associations and 6 positive.We found a causal relationship between cerebral aneurysm and Firmicutes (p = 0.024, IVW), suggesting a bidirectional causal relationship between cerebral aneurysm and Firmicutes. CONCLUSION: There may exist a potential correlation between oral microbiome and cerebral aneurysm within the East Asian population. The present study offers novel insights into the correlation between oral microbiome and cerebral aneurysms. Additional research is required to clarify the underlying mechanisms and validate our discoveries in diverse populations.