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May 4, 2026MedicinaOpen Access

Capsular Contracture in Implant-Based Breast Reconstruction: A Comprehensive Narrative Review of Pathophysiology, Risk Factors, and Contemporary Controversies

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Authors

MIMihai Iliescu-GlajaFSFabiana SimionDSDana STOIAN

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Overview

This narrative review explores capsular contracture in implant-based breast reconstruction, highlighting risk factors and treatment debates.

Key Points

  • The review aims to synthesize evidence on capsular contracture in implant-based breast reconstruction, focusing on risk factors and pathophysiology.
  • Comprehensive review of contemporary evidence, including meta-analyses and national registries.
  • Examination of factors such as implant surface characteristics, placement planes, and the role of acellular dermal matrices.
  • Discussion of current controversies regarding diagnostic criteria and optimal radiation sequencing.
  • Clinically significant capsular contracture occurs in 3-5% of non-irradiated patients and 20-50% in those receiving postmastectomy radiation.
  • Risk factors include implant characteristics, placement techniques, and radiation therapy specifics.
  • Proposed a clinical decision framework for individualized surgical approaches to mitigate capsular contracture risk.

Cite This Study

Iliescu-Glaja et al. (2026) studied this question.

synapsesocial.com/papers/69f837933ed186a739981c54https://doi.org/10.3390/medicina62050831
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