Optimizing Conditions for the Formation of Calcium Oxalate Trihydrate Using Response Surface Methodology

Nives Matijaković; Arijana Hamzić; Nikolina Filipović; Jelena Brdarić Kosanović; Imre Szenti; Marija Banožić; Anamarija Stanković

doi:10.1039/d6ce00201c

January 1, 2026CrystEngCommOpen Access

Optimizing Conditions for the Formation of Calcium Oxalate Trihydrate Using Response Surface Methodology

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Key Points

This research aims to identify optimal conditions for the formation of calcium oxalate trihydrate using response surface methodology.
Utilized response surface methodology to analyze the formation conditions of calcium oxalate trihydrate.
Tested various parameters affecting the formation process.
Conducted experiments to evaluate the stability of different hydrated forms.
Identified optimal conditions leading to increased formation rates of calcium oxalate trihydrate.
Quantified the influence of variables on the formation process, demonstrating significant interactions.
Confirmed the metastable nature of calcium oxalate trihydrate under specific conditions.

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Implication

Study optimizes calcium oxalate trihydrate formation conditions, indicating effective methodologies for minimizing kidney stone risk.

Abstract

Calcium oxalate (CaOx), the main component of kidney stones, occurs in several hydrated forms, among which calcium oxalate trihydrate (COT) is a rare and metastable phase believed to act as...

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Cite This Study

Matijaković et al. (2026) studied this question.

synapsesocial.com/papers/69f837c23ed186a739981fb9 https://doi.org/10.1039/d6ce00201c

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Optimizing Conditions for the Formation of Calcium Oxalate Trihydrate Using Response Surface Methodology

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Optimizing Conditions for the Formation of Calcium Oxalate Trihydrate Using Response Surface Methodology

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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