Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 4, 2026SHILAP Revista de lepidopterologíaOpen Access

Long-term consequences of prenatal saccharin exposure: evidence of sex-specific molecular programing in the prefrontal cortex and behavior of adolescent rats

View Full Paper
Ask AI
Bookmark
Share

Authors

BPBeatriz Pacheco-SánchezBPBeatriz Pacheco-SánchezRLRaquel López-Merchán

Discussion

Loading...

Member takes

Overview

Randomized trial assesses saccharin's impact on behavior and brain development in adolescent rats, suggesting lasting effects.

Key Points

  • The study aims to determine the long-term effects of prenatal saccharin exposure on behavior and molecular programming in adolescent rats.
  • Pregnant rats were administered 0.1% saccharin in drinking water throughout gestation.
  • Offspring were assessed behaviorally on postnatal day 21 using the open field and elevated plus maze tests.
  • Brain samples, particularly the prefrontal cortex, were collected for gene expression analysis at sacrifice.
  • Offspring of saccharin-consuming mothers showed sex-specific behavioral changes, with females having increased open-arm entries.
  • Only male pups showed significant increases in glutamatergic receptor gene expression, while females exhibited reduced GABAergic receptor expression.
  • Both sexes showed alterations in signaling pathways related to insulin, indicating neurodevelopmental impact.

Cite This Study

Pacheco-Sánchez et al. (2026) studied this question.

synapsesocial.com/papers/69f837d73ed186a739982241https://doi.org/10.3389/fnbeh.2026.1815692
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 17561 Maternal Sucrose Consumption During Gestation Alone Does Not Affect Glucocorticoids and Aldosterone in the Fetal Brain and Blood of Rats2024
  2. 2Impact of excessive sucrose intake on mouse behavior across different developmental stages2024 · 2 citations
  3. 3Maternal monosaccharide diets modulate melanocortin-4 receptor signaling and metabolic state in rat offspring2025
  4. 4Prenatal fructose exposure independently impacts placental phenotype and female offspring kidney function and liver composition in rats2025
  5. 5Maternal sucrose intake during pregnancy alone disrupts testosterone and allopregnanolone levels in the fetal brain of rats2025