The Indications and Effects of Ellagic Acid on Transmembrane Receptors in Cancer Types

Q: What does this research mean for the field?

Ellagic acid exerts broad anticancer effects across multiple cancer types by inhibiting key transmembrane receptors (such as VEGFR-2, EGFR, and PDGFR) and modulating downstream oncogenic signaling pathways including PI3K/AKT/mTOR and MAPK. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Soykan Ağar; Esra Acar; Erfan Akhavan; Erkan Gokoluk; Ebru Öztürk; Fadime Elmas Türkmen; Ayşe Elbay; Mahide Nur Mut; İdil Ayça Furunci; Ghassan İSSA; Jane Bogdanov

doi:10.66163/jokohtu.1910788

March 16, 2026Open Access

The Indications and Effects of Ellagic Acid on Transmembrane Receptors in Cancer Types

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Key Points

The aim is to summarize the interactions of ellagic acid with key receptors involved in cancer development.
Review of literature on ellagic acid and its effects on various transmembrane receptors in cancer types.
Analysis of pathways influenced by ellagic acid, including angiogenesis and inflammation mechanisms.
Ellagic acid inhibits key receptors like VEGFR-2, EGFR, and PDGFR, affecting oncogenic pathways.
It modulates hormone receptor signaling (ERα/ERβ, AR) and impacts apoptosis in cancer cells.
Ellagic acid shows potential in preventing various cancers including gastrointestinal, liver, breast, and lung cancers.

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Implication

Review summarizes ellagic acid's impact on cancer-related receptors, suggesting potential therapeutic applications.

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Cite This Study

Ağar et al. (2026) studied this question.

synapsesocial.com/papers/69f8380b3ed186a7399824bf https://doi.org/10.66163/jokohtu.1910788

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The Indications and Effects of Ellagic Acid on Transmembrane Receptors in Cancer Types

Key Points

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Implication

Abstract

Discussion

Cite This Study

The Indications and Effects of Ellagic Acid on Transmembrane Receptors in Cancer Types

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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