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This review aims to highlight the metabolic mechanisms and clinical efficacy of SGLT2 inhibitors in managing type 2 diabetes.

May 4, 2026AntioxidantsOpen Access

Sodium-Glucose Cotransporter-2 Inhibitors in Type 2 Diabetes: From Metabolic Mechanisms to International Guidelines

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Review discusses metabolic mechanisms and clinical significance of SGLT2 inhibitors in type 2 diabetes, indicating their broad utility.

This review aims to highlight the metabolic mechanisms and clinical efficacy of SGLT2 inhibitors in managing type 2 diabetes.
Summarizes metabolic and systemic effects of SGLT2 inhibitors based on recent clinical trials and preclinical studies.
Reviews international guidelines for the use of SGLT2 inhibitors in type 2 diabetes management.
SGLT2 inhibitors promote glycosuria, leading to a negative energy balance and modest weight loss.
They exhibit anti-inflammatory and antifibrotic effects via modulation of macrophage activity.
Clinical trials show significant reductions in heart failure hospitalizations and slower progression of chronic kidney disease.

Várkonyi et al. (2026) studied this question.

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