Treatment-resistant granulomatous periorificial dermatitis in a 14-year-old female: Resolution after oral isotretinoin and methotrexate – A case report

Childhood granulomatous periorificial dermatitis is an uncommon variant of periorificial dermatitis seen in patients under 18 years of age with several proposed triggers, including topical or inhaled corticosteroid exposure. We report and discuss a case of refractory childhood granulomatous periorificial dermatitis in a 14-year-old female with past inhaled corticosteroid use. After 7 months of isotretinoin therapy followed by 3 months of oral methotrexate, we observed complete resolution of her facial eruption.