What question did this study set out to answer?

To review the modular domain structure, diverse physiological roles, and pathological implications of the ADAM family of transmembrane metalloproteases.

January 1, 2003Genes & DevelopmentOpen Access

The ADAMs family of metalloproteases: multidomain proteins with multiple functions

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Authors

DSDarren F. SealsAppalachian State University SCSara A. CourtneidgeOregon Health & Science University

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Implication

Literature review uncovers the diverse functions of ADAM metalloproteases in cellular physiology and disease, indicating their therapeutic potential in inflammation and cancer.

Key Points

To review the modular domain structure, diverse physiological roles, and pathological implications of the ADAM family of transmembrane metalloproteases.
Synthesized molecular, structural, and functional evidence concerning the zinc-dependent ADAM metalloprotease family.
Evaluated mechanisms of integrin receptor-binding, cytoplasmic signaling, and substrate shedding across physiological processes and human disease states.
ADAM family proteins possess a modular design featuring metalloprotease, integrin-binding, and cytoplasmic domains that direct cell adhesion and intracellular signal transduction.
These proteases drive essential biological events, including cytokine and growth factor shedding, cell fusion, cell migration, muscle development, and fertilization.
Aberrant expression and dysregulated activity of specific ADAM members strongly associate with pathological inflammatory conditions and tumor progression.

Cite This Study

Seals et al. (2003) studied this question.

synapsesocial.com/papers/69f8ab2af896d0377df7681f https://doi.org/10.1101/gad.1039703

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Implication

Literature review uncovers the diverse functions of ADAM metalloproteases in cellular physiology and disease, indicating their therapeutic potential in inflammation and cancer.

The ADAMs family of metalloproteases: multidomain proteins with multiple functions

Discussion

Member takes

Implication

Key Points

Cite This Study

The ADAMs family of metalloproteases: multidomain proteins with multiple functions

Discussion

Member takes

Implication

Key Points

Cite This Study

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