New Chemotherapeutic Approaches to Treatment of Mesenchymal Triple-Negative Breast Cancer-Sensitive and Resistant to Cisplatin: Assessment of Cellular Response by Vibrational Microspectroscopy

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from phenylalanine of cisplatin-sensitive cells, while in cisplatin-resistant cells, proteins were the most affected cell components. These results provided spectral features specific to malignancy that led to discrimination between drug-treated and untreated cells. This knowledge is essential for the rational design of improved drugs with a higher efficiency coupled to lower toxicity.