Does Salvia miltiorrhiza Bunge root improve myocardial fibrosis?
Salvia miltiorrhiza Bunge root and its metabolites show promise as anti-fibrotic agents for myocardial fibrosis through pleiotropic mechanisms, warranting further clinical investigation.
radix et rhizoma], has gained attention for its potential in treating MF. Recent studies indicate significant therapeutic effects of its active metabolites, supporting its use in MF treatment and positioning it as a promising candidate for drug development. AIM OF THE REVIEW: Bunge," "extract," and "botanical drug." RESULTS: and its metabolite preparations exert anti-fibrotic effects through pleiotropic mechanisms, including suppression of ventricular remodeling, modulation of autophagy, inhibition of oxidative stress and cardiomyocyte apoptosis, and regulation of extracellular matrix homeostasis and immune-inflammatory responses. CONCLUSION: is beneficial for managing MF, but further studies are needed to identify its chemical metabolites and regulatory mechanisms. Large-scale, multi-center clinical trials are also necessary to assess treatment safety. This review offers insights for developing new anti-MF pharmacotherapies.
Li et al. (Mon,) studied this question.