Impact of Concomitant Mitral Regurgitation on the Hemodynamic Indicators of Aortic Stenosis

Figures

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  Figure 1. Effect of concomitant mitral regurgitation on left ventricle and aortic pressures waves for aortic stenosis (aortic valve area=1.0 cm2). A, Isolated aortic stenosis. B, Aortic stenosis with mild mitral regurgitation. C, Aortic stenosis with moderate mitral regurgitation. D, Aortic stenosis with severe mitral regurgitation. This figure shows the left ventricular and aortic pressure waveforms for isolated aortic stenosis (with preserved systolic function and an aortic valve area=1.0 cm2) and with worsening concomitant mitral regurgitation (mild, moderate, and severe) states. PAo indicates aortic pressure; and PLV, left ventricular pressure.

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  Figure 2. Effect of increasing severity of mitral regurgitation and decrementing aortic valve area on the transvalvular mean pressure gradient. This graph demonstrates the effect of increasing severity of mitral regurgitation on the relationship between mean aortic transvalvular pressure gradient and decrementing aortic valve area, in a simulation of aortic stenosis (with preserved systolic function). Note: red dotted line at 40 mm Hg represents mean pressure gradient threshold for severe aortic stenosis. MR indicates mitral regurgitation.