Time Course of Ischemic and Bleeding Burden in Elderly Patients With Acute Coronary Syndromes Randomized to Low‐Dose Prasugrel or Clopidogrel

Figures

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  Figure 1. Bleeding vs ischemic average event rate in the Elderly 2 ACS study patients. The 2 box plots show the distribution of average daily rate (ADR) of ischemic (red) and bleeding (blue) events within each clinical phase. The ADR was defined as the total number of events (numerator) divided by the patient‐days at risk (denominator). Patient‐days at risk were defined as number of patients multiplied by how many days each patient was at risk in that given period including partial intervals of patients who died or were lost to follow‐up. Green brackets show the least squares mean difference (LSMD), that is, the absolute difference of ADR of ischemic events vs ADR of bleeding events in the time course of 1‐year follow‐up. Positive LSMD indicates higher ADR for ischemic events than ADR for bleeding.

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  Figure 2. Average daily ischemic rates (ADIRs) for prasugrel 5 mg (light blue line) vs clopidogrel 75 mg (orange line) daily. The lines plot the ADIR as a continuous variable in the time course of follow‐up. The main panel shows the overall follow‐up time, the upper small panels show (with ad hoc magnification) the first 30 d (upper left) including the acute and the subacute phases, which are separated by a dotted vertical line, and the 31 to 365 d of follow‐up (upper right). The least squares mean difference (LSMD) indicates, within each clinical phase, the absolute difference of ADIRs between study arms; for example, positive LSMD indicates more events occurring in patients receiving clopidogrel 75 than in patients receiving prasugrel 5 mg. The higher the LSMD, the greater the magnitude of effect.

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  Figure 3. Average daily bleeding rate (ADBR) for prasugrel 5 mg (light blue line) vs clopidogrel 75 mg (orange line) daily. The lines plot the ADBR as a continuous variable in the time course of follow‐up. The main panel shows the overall follow‐up time; the upper small panels show (with ad hoc magnification) the first 30 d (upper left) including the acute and the subacute phases, which are separated by a dotted vertical line, and the 31 to 365 d of follow‐up (upper right). The least squares mean difference (LSMD) indicates, within each clinical phase, the absolute difference of ADBR between study arms; for example, negative LSMD indicates more events in patients receiving prasugrel 5 mg compared with patients receiving clopidogrel 75 mg.