What question did this study set out to answer?

To determine how proviral integration sites and infected-cell proliferation contribute to the long-term persistence of HIV during suppressive antiretroviral therapy.

July 11, 2014Science

Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection

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To determine how proviral integration sites and infected-cell proliferation contribute to the long-term persistence of HIV during suppressive antiretroviral therapy.
Analyzed 534 HIV integration sites and 63 adjacent HIV env sequences from three participants (N=3) followed over 11.3 to 12.7 years of antiretroviral treatment.
Identified and tracked identical proviral integration positions across multiple cells to evaluate clonal cell proliferation over time.
Identical viral sequences integrated at matching genomic coordinates were detected across multiple cells in every participant, demonstrating persistent infected-cell proliferation.
Proviral integrations were significantly overrepresented in cancer-associated genes, recurrently targeting 12 specific genes across multiple participants.
The relative proportion of persisting proviruses residing within proliferating cells increased progressively over time on antiretroviral therapy.

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Implication

Longitudinal study reveals clonal proliferation of cells harboring HIV integrated into cancer genes in patients on antiretroviral therapy, suggesting integration promotes viral persistence.

Cite This Study

Wagner et al. (2014) studied this question.

synapsesocial.com/papers/69f9407a8f423e6aadee5ec1 https://doi.org/10.1126/science.1256304

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Implication

Longitudinal study reveals clonal proliferation of cells harboring HIV integrated into cancer genes in patients on antiretroviral therapy, suggesting integration promotes viral persistence.

Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection

Key Points

Discussion

Implication

Cite This Study

Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection

Key Points

Discussion

Implication

Cite This Study

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