What question did this study set out to answer?

This research aims to optimize zein-chitosan nanocomplexes for the co-delivery of 5-fluorouracil and silibinin to enhance anticancer effects in colorectal cancer.

May 5, 20260 citations

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Bioinspired zein-chitosan nanocomplexes for co-delivery of 5-fluorouracil and silibinin: Optimization, characterization and anticancer activity in colorectal cancer.

SGShyam Sudhakar GomteNational Institute of Pharmaceutical Education and Research JBJyoti BishlayDepartment of Pharmaceuticals APAmit Kumar PandeyDepartment of Pharmaceuticals

Key Points

This research aims to optimize zein-chitosan nanocomplexes for the co-delivery of 5-fluorouracil and silibinin to enhance anticancer effects in colorectal cancer.
Utilized quality by design (QbD) for engineering zein-chitosan nanocomplexes.
Characterized the nanocomplexes to assess their efficiency in drug delivery.
Tested the cellular uptake and effects on cell cycle arrest in colorectal cancer models.
QbD-engineered nanocomplexes showed improved cellular uptake compared to the control group.
Nanocomplexes induced cell cycle arrest in colorectal cancer cells.

Abstract

cell cycle arrest, and improved cellular uptake compared to control group. The current investigation suggests that QbD-engineered zein-chitosan-based-NX could be a promising therapeutic strategy for managing CRC.

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Cite This Study

Gomte et al. (Thu,) studied this question.

synapsesocial.com/papers/69f9886315588823dae17776 https://doi.org/https://doi.org/10.1016/j.ijbiomac.2026.152296

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