Axially Chiral Spiro Compounds with Heavier Group 14 Elements as Spiro-Centers.

Key Points

• The aim is to investigate the chiral resolution of axially chiral spiro compounds containing heavier Group 14 elements.
• Utilized high-performance liquid chromatography (HPLC) for chiral resolution attempts
• Explored various configurations of spiro compounds incorporating Ge with differing elements (Ch = S, Se)
• Successful identification of viable chiral resolution methods for the target compounds
• Demonstrated the potential of using heavier Group 14 elements for achieving axially chiral compounds