Upregulated Macrophage-inducible C-type Lectin on Intermediate Monocyte Facilitates T helper 17 cell Differentiation in Systemic Lupus Erythematosus.

Key Points

• The study aims to investigate the role of Mincle in T cell differentiation related to systemic lupus erythematosus.
• Evaluated Mincle expression in circulating monocytes and its effects on T cell differentiation.
• Used THP-1 and U937 cell lines to assess differentiation towards Th1 and Th17.
• Analyzed systemic inflammation and SLE progression in the context of Mincle upregulation.
• Mincle overexpression significantly promoted differentiation of naive T cells towards Th17
• Intermediate monocytes with upregulated Mincle showed increased Th17 response, correlating with SLE severity
• Enhanced Th17 differentiation was linked to aggravated systemic inflammation.