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This research aims to design and evaluate new derivatives that target fungal energy metabolism to enhance agricultural pest control.

May 5, 20260 citations

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Design, Synthesis, and Antifungal Evaluation of Novel α-Methylene-γ-Butyrolactone Derivatives Bearing a Diaryl Ether Moiety for Phytopathogen Control.

DYDeyou Yang LLL. Li HLHeng Li

Key Points

This research aims to design and evaluate new derivatives that target fungal energy metabolism to enhance agricultural pest control.
Synthesis of novel α-methylene-γ-butyrolactone derivatives with diaryl ether moiety.
Evaluation of antifungal activity against various phytopathogens through bioactivity assessment.
Analysis of the mechanism of action by examining binding to respiratory chain complex III.
Derivatives showed significant antifungal activity, exhibiting inhibition of mitochondrial ATP synthesis.
Enhanced control of phytopathogens was observed, supporting the potential of these compounds as fungicides.

Abstract

exerts its bioactivity primarily by binding to respiratory chain complex III, thereby inhibiting mitochondrial ATP synthesis and impairing fungal energy metabolism. This work provides valuable insights for the development of MBL derivatives incorporating a diaryl ether moiety as promising novel agricultural fungicidal and bactericidal agents.

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Yang et al. (Sat,) studied this question.

synapsesocial.com/papers/69f9889415588823dae17870 https://doi.org/https://doi.org/10.1021/acs.jafc.6c00722

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