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May 5, 20267 citations

Exposure to 6-PPD quinone inhibits ATP synthesis by causing damage on mitochondrial complex V in Caenorhabditis elegans.

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XHXin HuaDWD P Wang

Key Points

  • This study aims to evaluate the impact of 6-PPD quinone on ATP synthesis by targeting mitochondrial complex V in C. elegans.
  • Examined binding potential of 6-PPD quinone to specific proteins
  • Assessed ATP content in organisms post-exposure
  • Investigated direct effects on mitochondrial complex V
  • Exposure to 6-PPD quinone significantly reduced ATP content in C. elegans
  • Binding with mitochondrial complex V proteins indicated potential for disruption
  • Suggests a causal link between 6-PPD quinone exposure and impaired ATP synthesis

Abstract

contents. 6-PPDQ has potential to bind to ATP-2, F58F12.1, ASB-1, and Y82E9BR.3. Therefore, potential direct effect of 6-PPDQ exposure in disrupting complex V was suggested to decrease the ATP content in organisms.

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Cite This Study

Hua et al. (2026) studied this question.

synapsesocial.com/papers/69f988e215588823dae17c68https://doi.org/10.1016/j.envres.2026.124637
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