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May 5, 2026

Zebularine Boosts Imatinib Efficacy in Cells of Colorectal Cancer via Wnt-Survivin-P-Glycoprotein Pathway.

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Authors

YAYasmin M. AttiaAEAbeer ElkhoelyFAFatma M Abdelwahed

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Overview

Randomized trial investigates combination therapy's effects on apoptosis and oxidative stress in colon cancer cells, suggesting a novel treatment approach.

Key Points

  • This research aims to evaluate the synergistic effects of Zebularine and Imatinib in colorectal cancer cells and their potential as a novel therapeutic strategy.
  • Analyzed cell growth inhibition in HCT-116 cells treated with Imatinib and Zebularine
  • Assessed apoptosis via flow cytometry and gene expression by qPCR
  • Evaluated ZEB uptake using LC-MS/MS and monitored cell cycle progression
  • Imatinib and Zebularine inhibited HCT-116 cell growth in a concentration-dependent manner
  • Combination therapy significantly enhanced oxidative stress and increased apoptosis
  • The combination treatment downregulated EGFR and metastatic markers (MMP9, MMP2), while upregulating apoptotic markers like Caspase-9

Cite This Study

Attia et al. (2026) studied this question.

synapsesocial.com/papers/69f9894115588823dae18298https://doi.org/10.1002/jbt.70885
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  5. 5<p>Supplementary File.</p>2026