Transcriptomic alterations upon nuclear XIAP overexpression reveal IGFBP6/Wnt as a regulatory axis in breast cancer cell survival and chemoresistance.

Bruna dos Santos Mendonça; Renata Binato; Eliana Abdelhay; Nathália Silva de Lima; Wallace Martins de Araújo; Raquel Ciuvalschi Maia; Renato Sampaio Carvalho; Gabriela Nestal de Moraes

doi:10.1016/j.ejphar.2026.178876

April 30, 2026

Transcriptomic alterations upon nuclear XIAP overexpression reveal IGFBP6/Wnt as a regulatory axis in breast cancer cell survival and chemoresistance.

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Key Points

This research aims to explore how nuclear XIAP overexpression affects breast cancer cell survival and chemoresistance through transcriptomic changes.
Cells were manipulated to overexpress XIAP, leading to analyses of gene expression changes.
Transcriptomic data were analyzed to identify pathways related to cell survival and chemoresistance.
Nuclear XIAP overexpression resulted in significant alterations in gene expression related to cell growth.
The Wnt/IGFBP6 axis was identified as a key regulatory pathway involved in the effects of XIAP on breast cancer cells.

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Implication

Demonstrates the role of nuclear XIAP in cell survival and chemoresistance via the Wnt/IGFBP6 axis in breast cancer.

Abstract

-overexpressing cells. Our data establishes a non-canonical role for XIAP in the regulation of pathways related to cell growth in the nucleus, with Wnt/IGFBP6 emerging as a potential regulatory node associated with nuclear XIAP effects in breast cancer.

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Mendonça et al. (2026) studied this question.

synapsesocial.com/papers/69f9895b15588823dae18514 https://doi.org/10.1016/j.ejphar.2026.178876

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Transcriptomic alterations upon nuclear XIAP overexpression reveal IGFBP6/Wnt as a regulatory axis in breast cancer cell survival and chemoresistance.

Key Points

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Implication

Abstract

Discussion

Cite This Study

Transcriptomic alterations upon nuclear XIAP overexpression reveal IGFBP6/Wnt as a regulatory axis in breast cancer cell survival and chemoresistance.

Key Points

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Implication

Abstract

Discussion

Cite This Study

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