Expiratory lung MRI: a simple, sensitive method to quantify and visualise regional gas trapping in cystic fibrosis.

Amy V Simmons; Laurie Smith; Zoe Somerville; Hannah Faulke; William Clark; David Hughes; Ina Aldag; Noreen West; Alberto Biancardi; Jim M. Wild; Neil J. Stewart

doi:10.1016/j.jcf.2026.04.008

May 1, 2026

Expiratory lung MRI: a simple, sensitive method to quantify and visualise regional gas trapping in cystic fibrosis.

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Key Points

This research aims to evaluate a new MRI technique to visualize and measure gas trapping in cystic fibrosis patients.
Used Xe Ventilation MRI for imaging gas trapping.
Measured ventilation defect percentage and gas trapping with body plethysmography.
Identified a significant percentage of ventilation defects using Xe-MRI.
Quantified gas trapping via body plethysmography, specifically RV/TLC%.

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Implication

Demonstrates a sensitive method to quantify gas trapping in cystic fibrosis, indicating improved diagnosis possibilities.

Abstract

BACKGROUND: H-MRI to visualise and quantify gas trapping in pwCF. METHODS: Xe Ventilation MRI. RESULTS: Xe-MRI ventilation defect percentage, and gas trapping measured by body plethysmography (RV/TLC%). CONCLUSIONS: .

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Cite This Study

Simmons et al. (2026) studied this question.

synapsesocial.com/papers/69f9898f15588823dae1862f https://doi.org/10.1016/j.jcf.2026.04.008

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Expiratory lung MRI: a simple, sensitive method to quantify and visualise regional gas trapping in cystic fibrosis.

Key Points

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Abstract

Discussion

Cite This Study

Expiratory lung MRI: a simple, sensitive method to quantify and visualise regional gas trapping in cystic fibrosis.

Key Points

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Implication

Abstract

Discussion

Cite This Study

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