What question did this study set out to answer?

To determine whether circulating long non-coding RNAs, particularly plasma POU3F3, can serve as stable, non-invasive diagnostic biomarkers for esophageal squamous cell carcinoma.

January 1, 2015Molecular CancerOpen Access

Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma

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To determine whether circulating long non-coding RNAs, particularly plasma POU3F3, can serve as stable, non-invasive diagnostic biomarkers for esophageal squamous cell carcinoma.
Screened 10 candidate lncRNAs previously identified as dysregulated in esophageal cancer across a four-stage exploratory framework.
Optimized plasma and serum detection assays, confirmed circulating lncRNA stability, and verified tumor cell origins in vitro and in vivo.
Evaluated diagnostic accuracy of individual and combined plasma lncRNAs and squamous cell carcinoma antigen using receiver operating characteristic analysis.
Circulating levels of POU3F3, HNF1A-AS1, and SPRY4-IT1 were significantly higher in patients with esophageal squamous cell carcinoma than in normal controls.
Plasma POU3F3 exhibited the highest standalone diagnostic accuracy among tested lncRNAs (AUC = 0.842, p < 0.001; sensitivity = 72.8%; specificity = 89.4%).
Combining POU3F3 with SCCA enhanced diagnostic efficacy (AUC = 0.926, p < 0.001; sensitivity = 85.7%; specificity = 81.4%) and detected 80.8% of early-stage tumors.

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Implication

Exploratory biomarker study reveals elevated plasma POU3F3 in esophageal squamous cell carcinoma patients, indicating high potential for non-invasive early tumor detection.

Cite This Study

Tong et al. (2015) studied this question.

synapsesocial.com/papers/69fa182917f63a043ab4b649 https://doi.org/10.1186/1476-4598-14-3

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Implication

Exploratory biomarker study reveals elevated plasma POU3F3 in esophageal squamous cell carcinoma patients, indicating high potential for non-invasive early tumor detection.

Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma

Key Points

Discussion

Implication

Cite This Study

Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma

Key Points

Discussion

Implication

Cite This Study

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