Why the study?
AF and MI are commonly comorbid and linked to adverse outcomes, but little is known about the impact of AF on quality of life and outcomes post-MI.
Does the presence of atrial fibrillation worsen quality of life and increase adverse clinical outcomes in stable patients post-myocardial infarction?
Does the presence of atrial fibrillation worsen quality of life and increase adverse clinical outcomes in stable patients post-myocardial infarction?
In stable patients post-MI, comorbid atrial fibrillation is associated with significant undertreatment with oral anticoagulants, poorer quality of life, and an increased risk of all-cause hospitalization.
AF associated with higher hospitalization post-MI; leaves open whether anticoagulation optimization reduces events.
OBJECTIVE: Atrial fibrillation (AF) and myocardial infarction (MI) are commonly comorbid and associated with adverse outcomes. Little is known about the impact of AF on quality of life and outcomes post-MI. We compared characteristics, quality of life and clinical outcomes in stable patients post-MI with/without AF. METHODS/RESULTS: -VASc score ≥2 was present in 686/702 (97.7%) patients with AF, although only 348/702 (49.6%) were on oral anticoagulants at enrolment. Patients with AF had higher rates of all-cause hospitalisation (adjusted rate ratio 1.25 [1.06-1.46], p=0.008) over 2 years than those without AF, but similar rates of mortality. CONCLUSIONS: In stable patients post-MI, those with AF were commonly undertreated with oral anticoagulants, had poorer quality of life and had increased risk of clinical outcomes than those without AF. TRIAL REGISTRATION NUMBER: ClinicalTrials: NCT01866904.
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Carnicelli et al. (2021) studied this question.
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