Key result
Baseline AF in post-MI LV dysfunction linked to ~32% higher mortality.
Why the study?
The frequency and impact of atrial fibrillation on clinical outcomes in patients with acute myocardial infarction complicated by left ventricular dysfunction were not well defined.
Does atrial fibrillation increase the risk of mortality and stroke in patients with acute myocardial infarction complicated by left ventricular dysfunction?
Cohort (n=5,477)
Does atrial fibrillation increase the risk of mortality and stroke in patients with acute myocardial infarction complicated by left ventricular dysfunction?
Hazard Ratio: 1.32
p-value: p=0.001
In patients with AMI complicated by heart failure, both pre-existing and new-onset atrial fibrillation are associated with a significantly increased risk of death and stroke.
No takes yet. Share an insight, caveat, or question.
AF signals higher mortality/stroke risk in AMI with LV dysfunction; extends observations but leaves causal and therapeutic questions open.
Mika Lehto (2004) conducted a cohort in acute myocardial infarction and left ventricular dysfunction (n=5,477). Atrial fibrillation (baseline or new-onset) vs. No atrial fibrillation was evaluated on mortality (HR 1.32, p=0.001). Baseline atrial fibrillation in patients with acute myocardial infarction and left ventricular dysfunction was associated with increased mortality (HR 1.32, P=0.001) and stroke (HR 1.77, P<0.001).
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