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April 5, 2005CirculationOpen Access

Time Dependence of Platelet Inhibition After a 600-mg Loading Dose of Clopidogrel in a Large, Unselected Cohort of Candidates for Percutaneous Coronary Intervention

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Why the study?

Does a 600-mg loading dose of clopidogrel achieve maximal platelet inhibition within 2 hours in patients scheduled for PCI?

Population

1001 patients scheduled for cardiac catheterization as potential candidates for percutaneous coronary…

Comparison

Clopidogrel 600 mg loading dose vs Different time intervals after administration…

Design

Cohort

Follow-up

30-day

Authors

WHWillibald HochholzerFondazione Edmund MachDTDietmar TrenkInterventional CardiologyDFDevine FrundiUniversity of Bern

Discussion

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Implication

Supports maximal inhibition by 2 hours after 600-mg clopidogrel; leaves open randomized confirmation for PCI timing and statin interactions.

Structured PICO

Does a 600-mg loading dose of clopidogrel achieve maximal platelet inhibition within 2 hours in patients scheduled for PCI?

P
Population
1001 patients scheduled for cardiac catheterization as potential candidates for percutaneous coronary intervention (PCI)
I
Intervention
Clopidogrel 600 mg loading dose
C
Comparator
Different time intervals after administration (<1 hour, 1 to <2 hours, 2 to <4 hours, 4 to <6 hours, and ≥6 hours) and baseline before administration
O
Outcome
Platelet aggregation by optical aggregometry and surface expression of P-selectin and activated glycoprotein IIb/IIIa by flow cytometrysurrogate

A 600-mg loading dose of clopidogrel achieves its full antiplatelet effect after 2 hours, and this effect is not attenuated by CYP3A4-metabolized statins.

Cite This Study

Hochholzer et al. (2005) studied this question.

synapsesocial.com/papers/69fa86a65e51e5e53523ca49https://doi.org/10.1161/01.cir.0000160869.75810.98

Topics

Dual antiplatelet therapyStatin therapy
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Statins on Platelet Inhibition by a High Loading Dose of Clopidogrel2003 · 127 citations
  2. 2Effect of a high loading dose of clopidogrel on platelet function in patients undergoing coronary stent placement2001 · 407 citations
  3. 3Antiplatelet effects of a 600 mg loading dose of clopidogrel are not attenuated in patients receiving atorvastatin or simvastatin for at least 4 weeks prior to coronary artery stenting2004 · 95 citations